As hair thinning, recession, and balding affects millions of men and women worldwide, it’s no wonder there are always new treatment methods coming onto the market. One such method is Platelet-Rich Plasma (PRP), and it’s being used with high success around the world (1).
In this post, I’ll introduce PRP and what it may mean for hair loss sufferers. This will include a look at how PRP is performed, how it works, as well as the scientific evidence behind it. I’ll also highlight a few alternatives.
What is Platelet-Rich Plasma (PRP)?
There are two definitions of PRP which I’ll be digging into today. The first is the literal definition, and the second is the definition as it refers to the hair loss treatment method.
First, the literal definition.
Platelet-rich plasma is a ‘product’ derived from whole blood. It’s a concentrate of platelet-rich plasma protein where the platelets and growth factors has been separated from the other blood products (including red blood cells) with a centrifuge.
Platelet Rich Plasma (PRP) is a serum created from your own blood; it’s filled with a concentration of cells called platelets, which are an important healing component of your blood. Platelets are made up of growth factors, proteins and cytokines— all things that help you repair damage and recover from wounds.
Think of platelets as the “quarterbacks” of your body’s healing system; they play an incredibly vital role by releasing growth factors and encouraging your body’s repair response. They’re so effective that they’ve been used for treatments ranging from healing sports injuries to heart transplants.
Now, what does this all have to do with hair growth?
Well, there’s a second definition of platelet-rich plasma, and that definition refers to a use as a treatment method for hairline recession and thinning.
PRP is a non-surgical method that uses your own blood to generate growth. This is done with tiny injections into the affected areas of the scalp, and it can be used in conjunction with other treatment methods (such as hair transplantation) or alone.
How Is PRP Performed?
There are two stages to PRP hair loss treatment.
First, blood is drawn from the patient and that blood is separated using a centrifuge. The separation occurs between the plasma and the red blood cells.
Second, the plasma is extracted from the collected blood and injected into the patient’s scalp where shedding has occurred. Multiple injections are performed in one session, and a typical session lasts about 60 minutes.
How Does PRP Treatment Work?
It seems a bit odd to draw blood from your body only to then reinject a portion of that blood again. So, what’s the deal?
It first helps to understand the proteins and other components present within the blood’s plasma.
As mentioned above, plasma acts as a reserve for proteins. However, plasma also contains its own proteins, as well as Growth Factors (GFs) (2). A few of the more important GFs include:
- Platelet-derived growth factor (PDGF)
- Transforming growth factor-beta (TGF-β)
- Vascular endothelial growth factor (VEGF)
- Epidermal growth factor (EGF)
- Insulin-like growth factor (IGF)
While each GF works differently, they all have a similar end goal: to promote cell proliferation and differentiation. This is believed to be done through stimulation of stem cells within the follicle giving rise to new hair (3).
Stem cells – undifferentiated cells that are capable of adapting into other cell types during development and growth – actually play a significant role in hair growth (4, 5). They are located at the bulge of the follicle – the area where new follicular units are formed – and when activated, can contribute to the formation and elongation of new follicles and hair strands.
As discussed, the GFs present within plasma can stimulate these cells.
Additionally, PRP is believed to stimulate blood flow to the area. This provides the hair follicles with vital nutrients and oxygen and leaves them in a healthier, stronger state.
The Scientific Evidence
While PRP is still undergoing extensive scientific testing, we do have the results of a few previous studies. There’s still much that’s unknown about platelet-rich plasma in the treatment of hair loss, but the little we do know is promising.
Universitat Internacional de Catalunya (Spain), 2015
This study is one of the larger-scale studies on PRP with 25 volunteers participating (6). The study was double-blind, and each volunteer received treatment on one side of the scalp and a placebo treatment on the other side.
A total of 3 PRP treatments was performed, each 1 month apart.
Three months and six months after initial treatment, volunteers were assessed for hair density and growth when compared to baseline. As discovered, the side of the scalp to receive PRP saw an increase in anagen hairs and in hair density when compared to the control side.
With such positive results, researchers concluded that PRP could certainly be a suitable treatment for Androgenetic Alopecia.
Catholic University of the Sacred Heart (Italy), 2015
In this placebo-controlled study, 23 male subjects participated overall (with three being excluded at the end of the study period) (7). Subjects were between the ages of 19 and 63, and all had at least a IIa on the Hamilton-Norwood classification scale.
All subjects were treated with PRP. However, the injection site varied by individual, and the trichologists who studied results were blinded to the groupings.
Evaluations were performed in six stages (T0, beginning of study; T1, 2 months; T2, 6 months; T3, 12 months, T4, 16 months; and T5, 24 months). Additionally, various evaluation methods were used, including global photography, physician’s and patient’s global assessment scale, and standardized phototrichograms.
As seen by researchers and participants, hair growth results (including hair growth count and density) were favorable even as early as 14 weeks post-treatment:
While these results seem impressive, what does this look like in reality?
Santosh Medical College (India), 2015
This smaller-scale study – consisting of 20 participants in all (10 treatment, 10 placebo) – also shows promising results for hair loss sufferers (8).
For 3 months, patients were injected with PRP every 2-3 weeks. At the end of the study, a look at results (including hair counts, hair thickness, hair root strength, and overall alopecia) was done.
In the ten subjects who received treatment, these were the hair pull test results:
As is seen above, there was an average reduction in hair loss during the hair pull test of 65%!
Researchers claim “hair growth was seen in six patients after 7 days and in four patients after 15 days. By the end of 3 months, all ten patients had good hair growth.”
Who Is a Candidate for PRP?
While there aren’t any explicit recommendations, there are a few people who will experience the best results. Such people include:
- Men and women who’ve experienced natural thinning and balding
- Men and women with location-based hair loss (such as the temples and crown)
- Men and women who are overall healthy.
Patients with early signs of balding will likely see the most favorable results, however patients at any point on their journey may see positive effects.
If you’re currently ill or undergoing treatments that are known to cause hair thinning and shedding (such as chemotherapy), it’s suggested you wait until the illness/treatment is complete.
Are There Any Side Effects or Considerations?
While trials are still underway, there’s no definitive answer as to side effects. However, current studies show that the risk of side effects is minimal.
As the treatment involves the use of a patient’s own blood products, it makes sense that side effects commonly seen in hair loss treatments (such as hair transplants and Rogaine/Propecia) aren’t present.
There are no foreign substances being injected into the body, and yet it still proves to be powerful enough to regrow hair.
You may experience minor irritation at the sites of injection, including itching, tingling, and redness. However, these irritations should go away within a day or so of treatment.
While not a side effect, you should also consider that results will vary. Your surgeon may be able to give you a general idea of results, but even these are estimates. Overall, I recommend you go in with conservative expectations.
How Much Does Platelet-Rich Plasma Therapy Cost?
The cost of treatment will vary by location, severity of hair fall, and surgeon. However, we can provide you with a few estimates based off of reviews from real users.
According to the prices submitted by 77 users on RealSelf, the average cost of PRP for hair loss across all locations costs $1,725. These ranged from as low as $50 to as high as $5,000. The average will vary slightly by location. For example, the average decreases to $1,500 when only looking at London, UK reviews.
Before moving forward, it’s best to consult with at least three surgeons who specialize in PRP in your area. Through these consultations, you’ll get a better idea of cost, how many sessions you’ll require, and what results you may be able to expect.
Is There An Alternative to Platelet-Rich Plasma Treatment?
As far as hair growth treatments go, PRP is about as natural as you can get. After all, the method uses your own blood to generate hair growth.
However, some may not be too keen to undergo this experimental treatment. So, what are the alternatives?
While the main mechanism behind PRP is believed to be stimulation of stem cells, another is stimulation of blood flow. The first cannot be achieved with microneedling, but the second certainly can!
Simply put, microneedling is a technique that involves the use of needles. Using a dermaroller, dermastamp, or dermapen, needles are applied to the area of the scalp affected by hair loss. These needles then create micro wounds, and a three-step process begins that includes:
- Maturation (Remodeling)
Microneedling can be performed by a dermatologist, or you can do it at home. All you need is a clean microneedling tool (such as a dermaroller).
Another newly-developed hair treatment method, laser therapy (or Low-Level Laser Therapy (LLLP)) can be a more cost effective alternative to PRP.
To understand how this works, it’s important to understand lasers.
Low-level lasers work by penetrating the scalp’s surface and interacting with specific cells within the hair follicles. As these cells are stimulated, the laser’s light is turned into energy which is then used to perform a number of hair growth processes (10).
As such, laser therapy is believed to (11):
- Stimulate the transition of telogen hairs into anagen phase
- Prolong the duration of anagen phase
- Increase rates of proliferation in active anagen hair follicles
- Prevent premature catagen development
All of these processes and more enable you to regrow your hair, and they can also make it possible to prevent future hair loss.
While you can undergo expensive LLLT in a specialist’s office, you can also perform the treatment at home. There are combs and helmets for this very purpose, and their use on a regular basis can work to bring your hair back to its natural glory.
Is platelet-rich plasma an effective hair loss treatment? Looking at the most recent scientific results, it appears to be. Of course, as the scope of treatment continues to widen, more research will become available.
However, if high-priced treatments aren’t something you’re interested in, there are lower cost options (such as microneedling and LLLT) available for you to consider.
*This article was reviewed by Dr. Anil Simhadri