Can RU58841 treat hair loss?

RU58841 – Everything You Need To Know – 3 Studies Show Hair Growth

In this article you’re going to learn about RU58841. You’ll learn what it is, how effective it is at reversing hair loss, how to use it, how to make it, and any associated side effects. You’ll see (from scientific studies) just how effectively this chemical can re-grow your hair.

If you have tried all sorts of drugs for hair loss, only to see disappointing results, you are definitely not alone.
In fact, this is actually what happens to many of the men experiencing some degree of baldness, or alopecia.

Despite extensive research and eager patrons, there are very limited options for drugs counteracting alopecia. Furthermore, many of these drugs prove to be either outright ineffective or gradually loses their potency after extended usage.

There is one other option that has long existed, but managed to slip under the radar: RU58841.

If you pride yourself on having extensive knowledge on the latest hair growth trends, you’ve probably heard of this obscure chemical. For everyone else, you’re probably wondering if this is an ingredient in some brand of lotion.

RU58841 (also known as RU-58841, PSK-3841 or HMR-3841) is a compound that has been garnering attention for its phenomenal response to hair growth, even for individuals who have exhausted all other methods.

Many claimed that this “magic pill” has helped grew back stubborn hairs in areas considered irreversibly damaged. Some have even regained a full bed of hair.

However, the FDA has not approved the use of RU58841. Nor can it be prescribed and sold at any pharmacies. Therefore, it is not officially available for commercial use and can only be obtained through dubious means.

Nonetheless, it is worth examining and dissecting this promising compound to fully assess whether it may be viable for you.

The Story of RU58841

RU58841 is not a recent invention; in fact, the idea was first conceived in the 1970s by scientists in France before moving onto research in the early 1990s.

They synthesized a novel non-steroidal, antiandrogenic compound designed to operate only at locally applied sites and avoid systemic effects.

After testing in vivo on hamsters and rats, the results came back very promising.

The local activities on both animals were shown to be significant, even at a dose as low as 1 microgram (0.001 milligrams). In addition, at higher doses (100 micrograms, or 0.01 milligrams), its action was limited only to the site of applications.

The researchers concluded that RU58841 might be useful for the topical treatment of androgen-dependent skin disorders, such as acne and alopecia.

But before any additional plans for research or production were confirmed, their company went through a merger with two other companies. Eventually, for reasons unknown, the project was dropped.

A few years later, another company called ProStraken acquired the rights to RU58841. Under ProStraken, it was renamed to PSK3841.

In 2005, the company announced plans to run a Phase II trial, with intentions of a full launch in 2010. Whether the phase II happened remains unclear.

As of now, there have not been any further signs of development for RU58841.

The Science behind Hair Loss

Before we go into further details about RU58841, let’s first explore the topic of androgen.

Androgens are important steroid hormones in charge of sexually related developments, both anatomically and physiologically. They are predominantly produced in the adrenal glands and sex organs of the respective gender (testes in men, ovaries in women).

The most active and well-known androgen is testosterone. Another widely established androgen is dihydrotestosterone (DHT), which is the byproduct of testosterone.

Androgens have an important role of controlling the maturation and maintenance of sexual characteristics.

For men, both testosterone and DHT are pivotal to the formation and growth of the penis, scrotum, and prostate. In addition, they are necessary for the process of spermatogenesis, or sperm production.

They also control many secondary male characteristics, such as the increase of muscle mass, deepening of the voice, and growth of body hair.

Around 5% of the free testosterone in the serum is transformed to DHT by enzymes called 5-alpha reductase. There are two forms of 5-alpha reductase: Type I and Type II.

Type I is expressed in the liver and sebaceous glands of the dermis. In the dermis, it is largely responsible for producing sebum, which is necessary for lubricating and protecting the skin from losing moisture.

Type II, on the other hand, is expressed in areas such as the prostate and dermal papilla cells of the skin. It contributes to the stimulation of the prostate and the hair follicles.

The active presence of these isoenzymes increases conversion of testosterone to the more potent and aggressive DHT.

As essential as DHT is for human functioning, the over-activation disrupts homeostatic balance in the body. In the scalp, it has shown to be the culprit for diminishing hair growth.

Why is DHT so Influential to Hair Loss?                         

Unfortunately, there are currently no clear explanations for the biological mechanisms involving DHT and alopecia.

However, there is a popular theory that for men who display genetic sensitivity to hair loss, DHT doesn’t directly cause hair to fall out – it restricts the follicles from being able to properly produce healthy, strong hair.

Once testosterone is converted to DHT, it heads directly to the hair follicles and finds the androgen receptors located on the dermal papilla cells.

Once it binds to the receptor, it is followed by the dissociation of protein complexes in the cytoplasm. This ultimately results in DHT entering the nucleus of the cell, where it disrupts with the follicle’s normal functions.

The compromised follicular cells will begin altering the growth cycle, most notably by reducing the duration of the anagen phase. When this happens, the cells that are rapidly dividing and forming the new hair will stop prematurely.

With each successive progression through the hair growth cycle, the hair strands will become thinner, shorter, and more brittle, making it easier to break or fall out. This is called miniaturization.

DHT can also stop essential vitamins, minerals, antioxidants, and proteins from nourishing the cells. This likewise will effectively reduce the average growth span of the follicles, further exacerbating development problems.

The overrepresentation of DHT will not be immediately obvious. A prolonged period of time will likely occur before the affected hair follicles show signs of unhealthy growth.

The Science behind RU58841

Many commercial drugs for hair loss, such as Finasteride (Propecia), works by specifically inhibiting 5-alpha reductase, an enzyme that converts testosterone into DHT.

However, reducing DHT count generally affects the individual on a systemic level, such that certain parts of the body that relies on DHT and other androgens to function may be compromised.

As mentioned before, RU58841 is an antiandrogenic compound, which means that it counteracts the effects of DHT and other androgens by attempting to inhibit the local androgen receptors at the hair follicles. I

n stopping androgens from binding to these receptors, the process of miniaturization never initiates, thus allowing the hair to undergo its normal growth cycle.

It also aids in cellular recovery by allowing time for damaged follicles to transition back to a normal anagen phase.

Since RU58841 does not actively seek to inhibit 5-alpha reductase from androgen conversions, the androgen counts of testosterone and DHT in the blood are presumably not affected.

There are few favorable studies indicating RU58841’s extraordinary abilities. However, after the rights for the RU58841 was transferred (and shelved), there have been little to no additional studies published.

Furthermore, none of the existing studies available have studied the side effects of long-term, extended use of RU58841.

Study #1. Follicular regrowth with 5 alpha-reductase inhibitors (finasteride) or androgen receptor blocker (RU58841)

An article from the Journal of Dermatology by researchers Uno et al examined the effects of two different antiandrogens on follicular growth and serum levels of testosterone and DHT: oral finasteride and topical RU58841.

The researchers chose to use the bald scalps of 20 macaques (monkeys).

In the study, finasteride (1mg/kg/day) and placebo were given to 10 macaques, while RU58841 were topically applied to 10 other macaques.

Skin biopsies for the hair follicles were taken at different times. For the finasteride, results were collected at 0 and 6 months, while the results for RU58841 were taken at 0 and 4 months.

Hair growth after 4 months using ru58841
Source.

First, they looked at the population of anagen follicles to vellus follicles. In the finasteride group, they observed an average of 88 percent increase in size. RU58841, on the other hand, showed a staggering 103 percent increase. Out of all the treatment groups, RU58841 induced the most growth after only 2 months.

The researchers also tested the level of serum testosterone and DHT. While the finasteride group showed a decrease in DHT and an increase in testosterone levels, the RU58841 exhibited no significant changes in DHT and testosterone levels.

The researchers concluded that blocking androgen receptors is more effective at suppressing testosterone and DHT-induced hair loss than targeting the enzyme 5-alpha reductase.

Study #2. Dose-dependent and long-term effects of RU58841 on hair regrowth

After the promising results shown in their first study, Uno et al. decided to further test the effectiveness of RU58841, but this time in different dosages.

Resuming their choice in macaques with bald scalps, they split twenty animals into five different groups: four experimental groups with RU58841 in 5, 3, 1 and 0.5 percent dosages and one placebo group. The solutions were applied topically once per day for 6 months.

In order to test the long-term effects, approximately three monkeys from each of the 5 percent, 0.5 percent, and placebo groups continued treatment for 12 to 24 months.

Their observation revealed that the group with 5 percent RU58841 showed a marked increase on all fronts, including density, thickness, and length of hair in as early as 3 months after treatment.

At the fifth month, the results showed that in addition to an average of two to threefold increase in the number of scalp follicles, they also have an increase of follicles in anagen phases.

Though there was noticeable growth in other groups, none showed results nearly as promising as the 5 percent group, with 1 and 0.5 percent being the weakest.

The macaques in the 5 percent group that continued the long-term treatment also showed progressive hair and follicular growth, which occurred continuously for 3 to 7 months. In all cases, post-withdrawal hair loss appeared after approximately 3 months.

The 0.5 percent group did not appear to have any noticeable progression after the initial minimal effects.

The researchers conclude that 5 percent of topical RU58841 not only induced remarkable effects on hair and follicular regrowth in such a short amount of time, but were also able to continue these effects with persistent use.

Study 3#. Controlled study of the effects of RU58841 on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice

Researchers Brouwer et al took twenty productive scalp grafts from middle-aged, balding men that have been maintained for 8 months and grafted them onto nude mice.

All mice were conditioned by the topical application of testosterone on the non-grafted flank.

The twenty grafted mice were randomly assigned to one of two different groups: the RU58841 experimental group and the control group.

In the experimental group, the grafted mice were topically applied with a 1 percent RU58841 solution. Meanwhile, the control group only received a topical application of ethanol solution.

The solutions were applied for 5 days a week and for a total of 6 months before the results were recorded.

On the control grafts, 28 active follicles appeared in total. Among them, only two follicles (7%) initiated a second hair cycle.

On the RU-58841 grafts, 29 active follicles appeared in total. However, eight of them showed a second growth cycle.

The researchers concluded that the value of linear hair growth rates was significantly higher in the group treated with RU58841 and may be useful in the treatment of androgen-dependent alopecia.

RU58851 Side Effects

Because there are no longitudinal studies that measured the side effects of RU58441, they are relatively unknown.

Any information about side effects is extracted from online testimonials and existing knowledge on physiological processes. Like any drugs, it may affect each and every user differently.

Unfortunately, systemic effects have been reported by many of those experimenting with the chemical. Some have been serious enough to warrant a discontinuation.

Given that RU58841 have only been available (for research purposes) in the last few years, certain chronic side effects have yet to be observed.

Remember, this drug not only blocks DHT and testosterone but ALL androgen. If even small traces of it are leaked into the serum, it will find and attach to any androgen receptors. It should, therefore, be used with great caution, preferably while consulting a healthcare provider.

Some reported side effects include the following:

  • Headache
  • Dizziness
  • Chest pain
  • Fatigue
  • Low libido
  • Erectile dysfunction
  • Low mood
  • Red eyes
  • Blurry eyes
  • Skin irritation

Where to Purchase it?

Currently, RU58841 is available for purchase online, with Kane and Anagen Inc as the more popular suppliers. However, it can only be purchased for research and laboratory experimentation purposes.

If you’ve thought it through and decided to try this out, then make sure to choose at least a 99% pure grade and read the label carefully to make sure that nothing appears out of place.

Keep in mind that because it is not FDA regulated, the powder may not be as advertised.

It may be more effective if you purchase the raw ingredients and mix it yourself.

Even though Kane and Anagen Inc offers the product pre-made for your convenience, there is no real guarantee on the concentration, quality, and purity of the pre-made mixtures.

One possible benefit of trying a pre-made mixture is to allow initial observations of any troubling side effects.

If your body reacts poorly, at least you knew before committing to expensive ingredients and equipment.

How to Make RU58851

You will need two basic components: RU58841, which comes in a bag of white powder and a vehicle. The RU58841 will go into the vehicle, which is then applied directly to the hair.

The vehicle helps effectively dissolve the powdered RU58841 into a liquid infusion, allowing it to penetrate past the skin barrier and deep into the hair follicles, where it will activate accordingly.

There are several options for the vehicle, depending on your preference.  Many choose the KB solution, available in the Kane Shop.

KB Solution Carrier is a pre-mixed vehicle that claims its ability to lower side effects by reducing the rate of absorption, thus encouraging the drug to stay locally on the scalp.

It also has the additional, but important, benefit of producing a protective film over the scalp after application. This will help prevent any undesirable transfers to others who may touch it by accident (such as expecting mothers).

Other available vehicle to consider is minoxidil (rogaine) which takes around 4 months to start seeing results. The RU58841 powder can be placed directly into a liquid solution of minoxidil. Please avoid minoxidil if it produces any unfavorable side effects.

If you want to cut cost and make your own mixture, below are the ingredients and recipe to assist you.

These instructions and measurements are tailored for those producing a fresh, daily batch. There are further instructions after if you want to produce larger batches.

Materials:

  • Raw RU58841 powder. You can order it from Kane, Anagen Inc, or other reputable companies in packages of 5g, 10g, or 20g
  • Small, accurate digital scale (make sure it goes to the third decimal, 0.001)
  • 1 ml dropper
  • Small measuring spoon
  • 20 ml glass bottle (for mixing PG and everclear together)

Vehicle (if forgoing pre-made solutions):

  • Propylene glycol
  • Everclear alcohol, 190 proof = 95%

Mixing Procedure:

  1. Take your glass bottle and place it on the digital scale. Press the TARE function so that the scale resets to 0. This is necessary in order to accurately weigh the powder and not the bottle.
  1. Take your RU58841 powder and scoop exactly 50 mg, or however much you would like to use. We DO NOT recommend exceeding more than 100 mg, as it can prove to be too potent and may further increase the chance of systemic absorption.
  1. Use your 1 ml dropper to extract 0.7 ml of everclear alcohol and place it in the bottle with the powder. Swirl or stir the mixture (be sure the stirring instrument is clean) until the powder has completely dissolved into the everclear.
  1. Use your 1 ml dropper again to extract 0.3 ml of propylene glycol and mix it with the powder and everclear. Wait for up to 5-10 minutes, occasionally swirling or stirring the mixture.Note: We are using a 70/30 percent ratio of everclear/propylene glycol. You are free to adjust the proportion as you see fit.

**If you want to make the solutions in larger batches, follow the instructions above, but take a 50 ml glass beaker and scoop ~2.5 grams of RU58841 instead. Dissolve the powder in 35 ml of everclear and 15 ml of propylene glycol. This will result in a 5% RU58841 in 50 ml, or 50mg/ml.

When and How to Apply

It is best to apply the solution within 20 minutes after washing and drying your hair. The sebum in the skin will make your scalp oily, thus reducing the effectiveness of the RU58841 solution.

Exfoliating before showering may also help shed the old, dead skin cells off the scalp’s surface and uncover fresh, new cells below.

However, try limiting the exfoliation to just once or twice a week, as over-exfoliating will leave the scalp red, tender, and sensitive.

Carefully apply the solution on affected areas of the scalp using the dropper. Make sure to also apply it in areas where you want to have hair maintained.

Because the solution is very watery, you can use gloved hands to help spread it evenly around.

Use the mixture once every day or two. It may take up four months before any intended results become noticeable.

How to Store it Properly

Although the manufacturers claims that it can be stored at room temperature for up to two weeks, we recommend placing the raw RU58841 in airtight bags and store it in the freezer to minimize degradation.

Make sure to keep it away from any light source, as it will accelerate the deterioration of RU58841 faster.

Any large batches or unused solution can be stored in the fridge for up to 4-7 days. However, if you want to make the most of the RU58841’s effect, you should consider making a fresh mixture every day.

Conclusions

Overall, RU58841 may prove to be a great asset in counteracting alopecia and promoting thick, healthy hair.

Because RU58841 was never given the proper scientific scrutiny it deserves, many aspects of this chemical remains shrouded in obscurity. Long-term side effects may not show until many years pass, where it may be too late to do anything.

Therefore, we do not recommend using it.

If you are still teetering, consider your other options first. Adjust for lifestyle changes, such as adopting a balanced diet or switching shampoo.

Look at drugs that have both their efficacy and safety well-recorded. RU58841 may be better considered as a last resort.

We highly recommend consulting a healthcare provider to help make an informed decision.

This is especially true if you are taking other medications or supplements, as the combination of RU58841 may interact with it negatively.

Please proceed with due caution and skepticism.

Disclaimer: Given the lack of peer-reviewed studies, we are not endorsing the use of this chemical. Any medical information in this article is provided as an information resource only.

Please do not use or rely on for any diagnostic or treatment purposes. This should not be used as a substitute for professional treatment.

Please consult your healthcare provider for any medical advice or decisions before adopting RU58841 into your regimen. If you experience any symptoms, contact your healthcare provider right away.

We are not responsible for any liability, damages, loss or injury as a consequence of your reliance on the information contained on this site.

References:

Battmann, T., Bonfils, A., Branche, C., Humbert, J., Goubet, F., Teutsch, G., & Philibert, D. (1994). RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. The Journal of steroid biochemistry and molecular biology, 48(1), 55-60.

http://www.gll-getalife.com/wp-content/uploads/2013/10/RU58841-A-New-Specific-Topical-Antiandrogen.-A-Candidate-of-Choice-for-the-Treatment-of-Acne-Androgenetic-Alopecia-and-Hirsutism-1.pdf

BROUWER, B., Tetelin, C., Leroy, T., Bonfils, A., & NESTE, D. (1997). A controlled study of the effects of RU58841, a non‐steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone‐conditioned nude mice. British Journal of Dermatology, 137(5), 699-702.
https://www.researchgate.net/publication/13815480_A_controlled_study_of_the_effects_of_RU58841_a_non-steroidal_antiandrogen_on_human_hair_production_by_balding_scalp_grafts_maintained_on_testosterane-conditioned_nude_mice

3 thoughts on “RU58841 – Everything You Need To Know – 3 Studies Show Hair Growth”

  1. I read somewhere that part of the reason that companies decided against commercializing RU58841 was because the liquid breaks down too quickly in the bottle and loses it’s effectiveness after a short time (1-2 months or something like that) which is obviously not an ideal product for a business to invest in, if it can’t sit on Pharmacy shelves long enough without going bad.

  2. I have been using this with Minoxidil, 5% solution for a year and a half. I haven’t experienced anything. Not even side effects. Regardless of the results of the promising studies its still hit and miss.

  3. Hi guys,

    After taking Ru 3 times I seem to be experiencing cheat pains/discomfort, shortness or breath, fatigue and sternum/back aches. Symptoms seem to come and go. I rush to hospital twice on the weekend and did an EGC, ECHO, xray and blood test all pass all test. I have no history of anxiety or stress or hypochondriac nature …or any family history of heart problems … I also visited a cardiologist and he couldn’t find anything… which seems to be a theme with other customer who’ve taken RU. I want to ensure I don’t cause any long term heart problems, so I’m writing to here to ask and warn people who have been on or thinking about taking RU : (….

    HELP—I really do need help here, can any one who has taken RU advise or someone in the medical field familiar with Androgen blockers advise how I can remedy the side effects asap as I don’t want any long term health issues.

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