It seems like we’ve been waiting for a hair loss breakthrough for a very long time. Every year, sufferers of male pattern baldness are told that a cure is just 5 years away.
Hair multiplication and cloning was expected to revolutionize the way that hair could be restored.
The basic premise was that you can take a hair from the back of the head and simply clone it, making multiple hundreds or thousands of similar hairs.
These hairs, when taken from the back of the head are not affected by DHT and don’t suffer from miniaturization, meaning they’re there for good.
Unfortunately, this hasn’t happened yet, or at least it isn’t available to the public, and scientists and researchers are still saying it’s 5 years away before this kind of procedure will be possible.
On the other side of the spectrum, the large pharmaceutical companies have been working to improve on the currently most effective drug, propecia.
Unfortunately, as many men who have tried it know, propecia (also known as finasteride) can have some very undesirable side effects, such as loss of libido, erectile dysfunction, and reduced ejaculatory volume, (plus many more.)
Propecia can also cause shedding to begin with.
I personally experienced these side-effects when I tried the drug and it’s clear to me now that the small reward just isn’t worth the risk.
Many men don’t even experience hair re-growth at all, and some continue to see a decline in hair coverage anyway.
Even further than improved development of Propecia, researchers have been making strides to discover new hair loss treatment drugs.
One such drug – currently in the beginning stages of testing – is SM04554.
Believed by many – researchers and hair loss sufferers alike – to be the “cure of the future”, this drug is known as the “miracle molecule”. Instead of blocking DHT (like Propecia), SM04554 works to enable a pathway known to cause hair growth (the Wnt pathway).
This is a natural process that takes place in the body, but one that’s blocked by a protein known as DKK1.
Researchers believe that SM04554 can inhibit DKK1 from stopping the Wnt pathway, and this will actually regenerate hair follicles and improve hair growth. That’s because the Wnt pathway plays a role in fetal development, and it can even induce dermal progenitor cells (similar to stem cells) to form a hair bulge.
Aside from the generation of new hair follicles, the Wnt pathway is also believed to initiate and maintain the anagen phase of hair growth. This is an essential step in the hair growth process, as anagen is the active phase of growth. With anagen initiated and prolonged, hair can grow (even from follicles that may have been previously miniaturized).
While this drug is still a long way from FDA approval, preliminary studies have already taken place.
The first study showed that SM04554 was overall safe for use, and it had very little in the way of side effects. The side effects that were present were mild and localized to the application site.
The second study focused on results, and they certainly look promising:
As seen above, follicle counts increased even after treatment had ceased (on Day 90), and both doses (0.15% and 0.25%) worked better than vehicle.
In addition, while the 0.25% solution seemed to be more effective, the 0.15% solution caught up in the end.
Finally, a larger-scale study was performed that contained over 300 male subjects.
Hair count and density increased in participants who received SM04554:
Interestingly, the treatment group who received the lower dose (0.15%) saw better results than the treatment group who received the higher dose (0.25%). According to researchers, this is known as the “Goldilocks effect”, but it may put a damper on further testing and development.
This is because scientists like to see results improve as dosage increases. Without this effect, it can make it difficult to know when to use which dosage, or even to understand when the drug would become lethal.
Luckily there are much more effective ways to beat hair loss without using drugs. And the only side effects are glowing health, increased libido and plentiful energy.
Side effects that come about through balancing your body and providing it with what it needs to grow hair, whilst removing the toxins and waste that causes hair loss in the first place. But more on that later.
The truth is, if you’re waiting for a hair loss breakthrough to come in the form of the drug you will be sorely disappointed.
Hair loss is, on a fundamental biological level, an imbalance in the body that causes hair to shed. Just look at how rates of male pattern baldness have increased over time, and correlate strongly with modern sedentary lifestyles and poor diets.
Where ever industrialization goes, over time, male pattern baldness follows.
The good news about this is, it means there is a lot you can do to slow down the process, and even reverse it. Back to the point though.
As pattern baldness is caused by biological imbalance, trying to make this right with a pharmaceutical is only covering things up. Yes it may work in the short term, but ultimately your body will pay the price down the road.
We all need to listen to what our body is telling us so that we can learn how to heal it for ourselves, naturally. In the long term, any drug will do more harm than good.
Why take the risk of interfering with your body and fighting the symptoms when you could easily correct hair loss naturally anyway.
Whether it’s a drug that inhibits 5-alpha-reductase to stop the production of DHT, or if it’s a new drug that inhibits Janus Kinase (JAK) (which puts hair follicles into a dormant phase) the result will be the same.
Learn more about JAK inhibitors here.
Tampering with the body in an unnatural way.
For me personally, and for most of the readers of this hair loss blog, we don’t want to wait, and we don’t want to interfere with our body in an unnatural way.
We’ve decided to try and cure our hair loss naturally. And for those who have already lost a significant amount of hair that is unrecoverable (the scalp heals over preventing any new hair from possibly growing) hair cloning may offer an acceptable solution.
In the mean time, the quickest way to combat hair loss is to remove the DHT from the scalp directly and then follow the lifestyle and dietary changes that I write about at the Hair Loss Revolution.
Update: I’ve just written an article about WAY 316606 which has recently been in the news as a potential fix for hair loss.
Have a question for me about the latest breakthrough, or something you want me to clarify? Just post a question or comment in the box above and I’ll try to answer asap – Will
How well does the Hair Equilibrium System work is it worth it to buy it , I’ve been suffering from hair loss for the past 5 years
It’s the most effective natural method that I know of. You can reasonably expect to at least stop any further hair loss. To re-grow hair takes longer and more effort but is totally possible if you stick with the equilibrium method.
Can you give me some advice on how to maintain hair after quitting minoxidil my doctor suggested me to use it.intially it did help to maintain my hair but there was no visible growth my dermatologist said that it will help you keep your existing hair.but after a year i got some side effects like itching and wrinkles so i decided to quit it it’s been 3 months now and my hairs are falling not so vigorously but slowly i used some oils and acv rinse and many more technique from your blogs and i think that is the reason hair fall is not so vigorous.i m really worried because i m in my 20’s.
I would recommend you check out this in-depth post written by Will here: https://www.hairguard.com/how-to-regrow-your-hair-naturally/
Hi, Will – what kind of shedding should I expect at the start of your system? I know hairfall is usually a sign of bad hair being replaced by “good hair” but shesding always scares me.
Does your elixir formula cause early shed, for example?
Hi Alan, it does depend. Yes sometimes shedding is unhealthy hairs being replaced. Especially with the scalp massages and exercises and small amount of shedding is okay, but it shouldn’t be a lot. If you’ve had a really unhealthy diet before then you may experience more shedding.
I have been bald for long time. I just want to enquire about possible drug that I can use to cure it, and where I can get it. From Nigeria
There is no magic cure for complete baldness. Typically the most you will be able to do, naturally, is re-grow the previous 5 years of lost hair. More than that is highly unlikely, unless your hair loss has taken place very slowly over a long period of time.
I have been suffering hair loss for a while, I’ve tried everything, from natural products to chemicals and nothing. I bought New Organic Shampoo on desperation.
i Didn’t know what to use. My hair was falling like crazy and I started seeing some patches in my head exposing my scalp. I’m 29 and always had nice long hair. At my early 20’s it started thinning and falling but just small amounts but 5 months ago it was too much. I started feeling depressed and seems that every product that I found contained lots of chemicals. I started using this shampoo on January 4th and I notice a difference the first time I used it.What I can say about the product:
1- the amount of hair that I lose in the shower was half of what I used to. It makes me think that with that being less it is giving my other new hairs time to grow.
2-volume in my hair, even though the dry climate didn’t help here.
3- my scalp felt less itchy
I will not ever buy a different shampoo and I recommend it to anyone that wants more, fuller, and healthier hair.
what kind of organic shampoo are you taking about?
What’s the name of the shampoo?
Hi, should we try hair transplant FUE instead?
Typically you will be able to regrow any hair lost in the last 5-10 years by completely natural means that I describe here. If you still have bald areas after that then you can start to consider a transplant.
I remember articles talking about baldness cure in 2013 then 2016 .. it’s always just “5 years” away. It’s all bullshit, search companies saying their “this close” to finding a cure and taking in hundreds of thousands of dollars for “research” I won’t be holding my breath.
Agreed. That’s why I always recommend keeping/regrowing as much hair as you can using the natural methods.
Been taken propecia for years but want to be all natural and have better results
Is genetic hairloss cureable??
The term ‘curable’ implies a disease in my mind, hair loss isn’t a disease so I don’t like to use a term like this. (Hair loss is a symptom of a bigger problem) Genetics do play a role, but is more accurately defined as a ‘genetic predisposition.’ But to give you a short answer, yes you can stop and reverse ‘androgenetic alopecia.’
Is it best to combat hair loss at an early stage? And
Provided you rely on natural method/Remedies would this be enough to regrow lost hair follicles?
It’s best to start with treatment as soon as you notice signs of loss. However, it’s impossible to regrow already dead follicles. But this is all the more reason to start treating your hair loss now.
My male pattern hair loss stopped 32 years ago when I had a procedure called the ligatures of the superficial scalp arteries. I had both my temporal and both my occipital scalp arteries ligated, and my hair loss completely stopped.I did not regrow lost hair, but my hair loss is very minimal, so I can hide my receded hairline. This procedure lowers the amount of testosterone being irrigated to the top of the head through blood. It really works, I am living proof.
That’s very interesting Peter. I’ve never heard of this procedure before. I wonder if this is a standard operation and if it was done for the purposes for stopping hair loss, or that was just one of the side-effects of the procedure.
I have 43years old. I am using lipogaine minox but still suffering hairloss and getting thin hair.
What product you recommend me?
I would recommend you check out this in-depth post on Will’s own hair regrowth journey: https://www.hairguard.com/how-to-regrow-your-hair-naturally/
I have a pretty good hairline,but I have very less hair strands at the top of my head (above the crown). I can’t use dermaroller coz I may end up losing the existing strands,also the products mentioned in this blog is highly costly in the place that I live in.Is there any methods to regrow all the lost strands.By the way I’m just 17 and I’m fearing hair loss!!!
Hello Benjamin, you could try using a dermastamp instead of a dermaroller. This will help you be more careful not to damage any exsisting follicles. You need to focus on your diet then, buying the right hair foods is often cheaper then more expensive but damaging foods. Also, stop using any kind of shampoos, they will only strip your hair of natural, protective oils.
Thanks for sharing an informative post. So many people are worried now for hair fall. Hair transplant is a good solution for growing black hair overhead. There are good facilities with new techniques for hair transplant in India. Recently my younger brother did Fue hair transplant there with affordable price.
I’m using sesame oil and I’m 17 to increase my hair density. Will it work?
Hi Rijul, you are using it internally, or topically? I would recommend other oils instead of sesame to be honest. Please take a look at our Scalp Secrets eBook for more information.
Do we need to use this product regularly like that of minoxidil?
Any kind of hair loss product needs to be used regularly to see results.
Where is the cure. So much talk … so misleading.
Stop beating around the bush and get to the point.
The point is… there is no ‘cure.’ There are lots of different things you can do which help overall, but no ‘magic bullet’.
Just eat healthy and avoid processed foods people people! Thats what worked for me!
That’s a great start! For some, though, it takes a bit more to regrow hair (especially if hair loss has continued for years).
Do the treatments you discuss on this blog also work for women? Do you suggest something different ?
For the vast majority of our recommendations, women can use them as well as men. If there’s ever an exception then it will be noted in the article.
I believe this post will be of help to you: https://www.hairguard.com/dandruff/
To get started with treatment, I recommend this guide: https://www.hairguard.com/scalp-secrets/
Please help on how to cure my baldness. My baldness seriously occurred in January 2018. I’m from Ghana and I became 31 years on October 15, 2018.
So please, how could I get your product?
I would recommend you check out Will’s guide Scalp Secrets. It will introduce you to the various techniques necessary to regrowing your hair so you can get started.
I had ligatures of my temporal and occipital scalp arteries 34 years ago, and at age 58 I have as much hair as age 24. This procedure really works and I am living proof.
Hey Will I just want to thank you for such amazing articles related to hairloss. You have freely made so much article available which helps young balding people like me who are studying and not earning right now. I have started diet and exercises from your article. I truly appreciate it. Thank you. Keep doing good work.
Thank you Rahul, your support keeps us going.