Rogaine vs. Generic Minoxidil: 5 Differences To Know Before You Buy!

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When it comes to hair loss treatment, Rogaine is a name that everyone knows. However, the generic rogaine brands can be just as effective (in addition to being cheaper).

In this article, I’m going to discuss the differences between Rogaine and generic minoxidil. I’ll discuss side effects and considerations, as well as where you can find and purchase different generic brands.

In addition, I’ll share a two-step process you can use to stop your hair loss and possibly even regrow your hair.

Rogaine (Minoxidil) To Treat Hair Loss

To understand how Rogaine differs from its various generics, it’s important to first understand its history and how it works.

Development & Use

Minoxidil is a drug that was originally developed in the late 1950s to treat ulcers. While trials proved that the drug didn’t do as scientists expected, it did prove itself to be an effective vasodilator.

In the 1960s and 70s, it was then developed as a treatment for high blood pressure (hypertension) (1). It was marketed under the name Loniten, and it was prescribed orally starting in 1979.

Another unexpected use of the drug – discovered during initial trials – was its effectiveness at the treatment of hair loss.

In fact, the drug was so widely known for its hair growth abilities, that doctors were prescribing it off-label to treat their patients who suffered from Male-Pattern Baldness (MPB).

In 1988, the product was FDA approved for use as a hair growth treatment (under the brand name of Rogaine), and in 1991 a solution was approved for women.

Finally, the product was approved as an over-the-counter formula in 1996.

How Does It Work?

While there’s still a bit of debate surrounding minoxidil’s exact mechanism, it’s believe that its vasodilating effects are the most likely cause of its positive effects (2).

But what does dilation of the blood vessels have to do with hair growth?

In individuals with MPB (medically referred to as Androgenetic Alopecia (AGA)), a sensitivity to DHT causes inflammation of the hair follicles.

DHT is produced from the interaction between testosterone (the male sex hormone) and 5-alpha-reductase (an enzyme), and it’s a normal process that occurs in all men.

Unfortunately, a genetic predisposition to AGA can put you at risk for DHT sensitivity, and this can lead to hair thinning and loss.

As DHT attaches to the androgen receptors at the follicles, the follicles near the front of the scalp and vertex react by inflaming. This leads to a process known as hair miniaturization.

As the follicles become inflamed and irritated as a result of DHT sensitivity, the hair cycle shortens leading to baldness.

As the follicle miniaturizes, the hair growth cycle shortens. This eventually leads to thinning and, if not treated, permanent baldness.

During this process, the blood flow to the hair follicle is also restricted. This means the follicles aren’t receiving the amount of oxygen and nutrients they need to thrive, and this further contributes to the miniaturization process.

As a vasodilator, minoxidil widens the blood vessels (3). The necessary elements can then once again make their way to the follicles (even those inflamed by the presence of DHT), and hair growth can occur.

Rogaine vs. Generic Minoxidil: What’s the Difference?

When a product such as Rogaine is patented, the originating company has exclusive rights to its formulation for 20 years (in the US, UK, and Canada). Once the patent runs out, other companies are then able to use the original formulation (with minor tweaks) for their own brands.

This is great for consumers, as Rogaine no longer has exclusivity on the hair loss treatment market.

Consumers can now purchase other brands – the majority of which are cheaper – and make an informed decision as to which one they like best.

These other brands are known as generics.

Two of the most popular generic brands are Kirkland (Costco) and Equate (Walmart). However, many stores have their own branded minoxidil products.

But what’s the difference between the original brand (Rogaine) and its generics?

The simple answer to the question is, “not much”.

The active ingredient minoxidil is the same within each product.

You will notice that each generic brand varies when it comes to inactive ingredients. This can change consistency and, therefore, the way in which each product applies.

However, the difference between products is typically negligible.

Of course, you may find brands that work better for your scalp than others.

For example, many users of Kirkland Signature Minoxidil (a Costco generic) find it’s greasier than Rogaine and other minoxidil-containing products. On the other hand, some users find Rogaine to be too drying.

When it comes down to it, the one you pick will depend entirely on preference and hair type.

How to Apply

Whether you use the name brand Rogaine or a generic brand, the application of each follows the same process (though, it does vary by solution).

Spraying Rogaine on the scalp

To apply the liquid, you use the applicator tool that’s attached to the lid. Simply collect 1 milliliter of the liquid in the tool, and add the drops to the balding areas of your scalp.

Work the liquid in with clean fingertips, and be sure to wash hands thoroughly. Do not shower or apply other products (including mousse, gel, or hairspray) for at least four hours.

The foam is much easier to apply, and it also dries more quickly. Use the foam applicator to put a dollop of foam in your hand. Use your fingers to apply the foam to the balding areas of your scalp.

Rub until the foam absorbs fully. Allow the foam to dry completely before styling. Wash your hands after, to remove the product from your fingers.

Side Effects & Considerations

As with any topical hair loss product, there’s always a risk of side effects. The most common associated with minoxidil solutions include local irritation (4). Symptoms of such irritation includes:

For many individuals, the symptoms ease as use continues or they’re not severe enough to discontinue use. However, some people will be more sensitive to the product than others.

If symptoms continue or worsen, it’s best to stop use and speak with a physician.

A more severe reaction can occur. Symptoms of such a reaction include hives, rash, difficulty breathing, and swelling of the lips, mouth, tongue, or throat.

If you experience a severe reaction, seek medical attention immediately.

In addition to adverse effects, however, there are also a few things to consider before using Rogaine or any other minoxidil products:

  1. Minoxidil is not a hair loss cure.
  2. Your hair loss can (and likely will) return once minoxidil use is stopped.
  3. Minoxidil doesn’t work for everyone.

In addition, it’s very common to experience shedding in the first few months of minoxidil use. This is a normal part of the process, as the hair follicles are cycling from telogen to anagen phase much more quickly.

For the majority of users, the excess shedding will subside in a few months’ time. However, some users are so bothered by the “side effect” that use is discontinued.

Availability and Cost

The majority of drug stores, both online and not, have their own brands of Rogaine product available for purchase.

The cost will vary based upon location, solution (liquid or foam) and strength (2% – 5%).

Learn more about high strength minoxidil here.

Some of the more popular brands, such as Kirkland and Equate, can be purchased online.

A 6-month supply of Kirkland Minoxidil Solution 5%, for example, can be purchased for $16.99 on the Costco website.

A Natural Alternative to Minoxidil Products (2 Steps)

As someone who’s experienced hair loss first hand, I understand what it’s like to want a quick fix. However, treatment options such as minoxidil do not treat the underlying cause of hair loss.

Here are the steps I recommend:

1. Find the Cause

While MPB can be genetic, this doesn’t mean there aren’t other causes contributing to the issue. To find these causes, I recommend this approach.

Do an Elimination Diet

While certain foods can be more likely to trigger hair loss, you may also have underlying allergies or sensitivities that are causing inflammation.

This inflammation can then further your odds of hair loss.

So, what can you do to narrow down your trouble foods?

An elimination diet is a multi-step program that involves cutting out many food groups and then slowly reintroducing them into your diet. As you introduce the food groups, you keep a journal tracking any symptoms.

Revamp Your Hair Care Routine

Whether you’re suffering from full baldness, or your hair has only begun to thin, you may not be aware that chemicals in popular hair products can further contribute to your hair loss woes.

Not only can shop-bought products – including shampoos, conditioners, and styling cremes – cause damage to your hair, but they can also further hair loss in people with AGA.

That’s not to say you should stop using over-the-counter products altogether. In fact, many may help you to combat hair loss.

But it’s important to know exactly what you’re putting on your scalp and how it may affect hair growth in the long run.

There are more natural formulations, such as Hairguard, that work to clean the scalp while also stimulating the follicles. And they can even be combined with more mainstream treatments (including minoxidil and finasteride), or similar alternatives.

There are other steps you can add to your routine, though, that also contribute to a healthy scalp.

For example, a daily ten-minute scalp massage and a weekly microneedling session can increase blood flow to the scalp. This boost of oxygen and nutrients will support stronger hair, and it may even help to combat the effects of many hair loss conditions.

Scalp massage has also been shown to reduce scalp tension – a likely contributor to pattern balding – and microneedling has been shown to induce collagen production and skin proliferation (5, 6, 7).

These two simple additions are just one way to revamp your routine with scalp health and hair growth in mind.

2. Treat the Issue

With a better understanding of your hair loss triggers, it’s now time to treat the issue at its source.

The actual treatment route you take will depend on cause.

Alopecia Areata (AA), for example, is an autoimmune hair loss condition that often requires you to work closely with a dermatologist (8). You may be prescribed steroids or anti-inflammatories, but you can also work with your doctor to find a more viable long-term solution (such as diet change).

AGA is similar in that it’s best to work with a dermatologist.

The most common treatment routes are minoxidil and finasteride but, as mentioned, these don’t treat the underlying problem. Instead, you may find it more beneficial to take a look at other triggers (e.g. diet, environment, lifestyle) and alter those.

That doesn’t mean that minoxidil and other mainstream options can’t be part of your treatment plan. But they shouldn’t be the be-all-end-all.

Your Diet and Hair Loss: How Deep Is the Connection?

As mentioned above, food sensitivities can cause inflammation and keep you in the hair loss cycle. However, there are other aspects of your diet that may be causing you more harm than you think.

While the modern day diet has strayed far from our ancestors’, there is one thing we can still do just like them: Eat foods that will heal our bodies.

By altering your diet – aligning it better with the diet of your ancestors – you can treat a significant trigger of hair loss.

So, how can you get started?

I believe that small steps will help you to build a firm foundation. With that in mind…

Reduce Your Intake of Unhealthy Fats

Fats are a necessary part of a healthy diet. However, modern foods are full of unhealthy oils, and they offer little in the way of nutrition or benefit.

It is crucial that you reduce your intake of unhealthy fats – such as those found in fried foods, in packaged snacks, and in high-fat cuts of meat.

Instead, you should focus on the consumption of natural foods that contain fats as a major part of their composition. For example, coconut, avocado, nuts (almond, chestnut, cashew), seeds (pumpkin, flax), and fish (especially cold water).

Increase Your Intake of Fiber

The health of your gut plays a key role in the health of your body. As such, it’s important to increase your fiber intake to clean out your intestines and keep your sugar levels even (9).

High-fiber foods are also more filling, and this can help you to cut back on junk foods.


Rogaine is a popular brand associated with the drug minoxidil, but it’s not the only brand available.

In fact, there are many store brand minoxidil products available on the market and the majority work just as effectively as Rogaine.